Pregnancy


PRINCIPAL BLOOD CHANGES  

Sr.No.
Blood
Non  Pregnant
Pregnancy
near term
Change
I
(1)    Blood Volume (ml)
4000
5500
+30-40%
(2)    Plasma Volume (ml)
2500
3750
+40-50%
(3)    Red Cell Volume (ml)
1400
1650
+18-20%
(4)    Total Hb (gm)
475
560
+18-20%
(5)    Haematocrit (whole body)
38%
32%
diminished
II
Leucocytes



(1)    Neutrophilic leucocytes
7,500-10,000 cm
10,000-15,000 cm
- 20,000 /cmm
­
III
Plasma Protein



(1)    Total Proteins
180
230
­
(2)    Plasma protein concentration (gm/100ml)
7
6
¯
(3)    Albumin (gm/100ml)
4.3
3
¯
(4)    Globulin (gm/100ml)
2.7
3
Slight ­
(5)    Albumin : Globulin
1.7:1
1:1
¯
IV
Blood coagulation factors




(1)    Platelets (/cmm)
18,00,000
Controversial observation
Static or 15% reduction of the count
(2)    Fibrinogen (mg%)
200-400
300-500
+50%
(3)    Fibrinolytic activity
-
Depressed 
-
(4)    Clotting time
-
Unaffected
-
(5)    ESR
10mm/hr
40mm/hr
Marked             (4 times) ­
V.
Blood Lipids (mg/100ml)



(1)    Total lipids
650
1000
+50%
(2)    Cholesterol
180
260
+40%
(3)    Phospholipids
250
350
+40%
VI
Haemodynamic changes



(1)    Cardiac output (lit/min)
4.5
6.26
+30%
(2)    Stroke volume (ml)
65
75
­
(3)    Pulse rate (/min)
70
85
­
(4)    Blood pressure
-
Unaffected            mid pregnancy drop of diastolic pressure
-
(5)    Venous pressure (femoral)
         (cm water)
8-10
20
+100%
(6)    Peripheral resistance

¯¯

(7)    Blood viscosity (relative
         to water)
4.7
3.8
Diminished